2. Signaling Pathways
  3. GPCR/G Protein
  4. Urotensin Receptor

Urotensin Receptor

UT receptor

Urotensin Receptor

Related Products

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Urotensin receptor (UT) is a G-protein coupled receptor which binds the peptide hormoneurotensin. The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney, although they are found elsewhere, notably the central nervous system, at lower levels. The UT receptor produces potent but variable vasoconstrictor effects in some vascular beds, yet mediates vasodilation in others; it has also been implicated in osmoregulation.

Urotensin Receptor Related Products (30):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1166A
    UFP-803 TFA
    		Antagonist
    UFP-803 TFA is a potent urotensin-II receptor (UT) ligand. UFP-803 TFA has lower residual agonist activity, so it may be an important tool for the investigations on the role played by the UT system in physiology and pathology.
    UFP-803 TFA
  • HY-P3957
    Urotensin II, teleost fish
    		Agonist
    Urotensin II, teleost fish is a cyclic peptide. It can be isolated from the caudal neurosecretory system of teleost fish.
    Urotensin II, teleost fish
  • HY-129648
    AC-7954 free base
    AC-7954 free base is a selective nonpeptidic urotensin receptor agonist (EC50: 300 nM at the human UII receptor).
    AC-7954 free base
  • HY-10655AR
    Palosuran hydrochloride (Standard)
    		Antagonist
    Palosuran (hydrochloride) (Standard) is the analytical standard of Palosuran (hydrochloride). This product is intended for research and analytical applications. Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats[1][2].
    Palosuran hydrochloride (Standard)
  • HY-10664R
    SB-611812 (Standard)
    		Antagonist
    SB-611812 (Standard) is the analytical standard of SB-611812. This product is intended for research and analytical applications. SB-611812 is a urotensin II receptor (UTR) antagonist with the potential in the research of cardiovascular disease[1][2].
    SB-611812 (Standard)
  • HY-P1168
    [Orn8]-Urotensin II (human)
    		Agonist
    [Orn8]-Urotensin II (human), a peptide analog of urotensin II, is a UT receptor agonist. [Orn8]-Urotensin II (human) increases intracellular calcium levels in HEK293.
    [Orn8]-Urotensin II (human)
  • HY-10658
    AC-7954
    AC-7954 is a selective nonpeptidic urotensin receptor agonist (EC50: 300 nM at the human UII receptor).
    AC-7954
  • HY-19924
    GSK-1440115
    		Antagonist
    GSK-1440115 is an antagonist of the Urotensin II Receptor with an IC50 value of 82.3 nM.
    GSK-1440115
  • HY-10655R
    Palosuran (Standard)
    		Antagonist
    Palosuran (Standard) is the analytical standard of Palosuran. This product is intended for research and analytical applications. Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats[1][2].
    Palosuran (Standard)
  • HY-10666
    SB-436811
    		Antagonist
    SB-436811 is a human urotensin-II receptor antagonist with a pKi value of 6.7.
    SB-436811